GMP Recombinant Human IL-23-武汉恩玑生命科技有限公司

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GMP Recombinant Human IL-23

品牌：EnkiLife

产地：中国

型号：支

货号：PCH90026

价格： ￥700/10μg
发布日期： 2024-11-30
更新日期： 2025-05-22

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产品详请

产地	中国
保存条件
品牌	EnkiLife
货号	PCH90026
用途	细胞培养用细胞因子
组织来源
细胞形态
是否是肿瘤细胞
保质期
器官来源
免疫类型
品系
生长状态
物种来源
包装规格	支
是否进口	否

产品名称	GMP Recombinant Human IL-23
蛋白名	IL-23
纯度	Greater than 95% as determined by reducing SDS-PAGE
内毒素	≤10 EU/mg
蛋白构建	Recombinant Human IL-23 is produced by our Mammalian cell expression system and the target gene encoding Ile23-Ser328&Arg23-Pro189 is expressed.
Accession #	P29460(P40), AAG37232(P19)
蛋白标签	Tag free
表达宿主	Mammalian cell
种属	Human
预测分子量	55.0 kDa(IL-23singlechain);36.5 kDa(p40)&18.5 kDa(p19)
蛋白形态	Lyophilized
储存缓冲液	PBS,5% mannitol and 0.01% Tween 80, pH7.4
运输方式	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
稳定性&储存	Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 33 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
复溶	Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

分子别名

SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2

Bioactivity

The ED50 for this effect is <0.5 μg/mL.

背景介绍

Interleukin-23 (IL-23) is a heterodimeric cytokine that belongs to the IL-12 cytokine family. It is composed of two subunits, p19 and p40, with the p40 subunit being shared with IL-12. IL-23 is primarily secreted by activated macrophages and dendritic cells located in peripheral tissues such as skin, intestinal mucosa, and lung. This cytokine plays a crucial role in the development and maintenance of autoimmune inflammation, particularly through its ability to induce IL-17 production, which is a unique role compared to IL-12.