GMP Recombinant Human TGF-β3-武汉恩玑生命科技有限公司

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GMP Recombinant Human TGF-β3

品牌：EnkiLife

产地：中国

型号：支

货号：PCH90042

价格： ￥2500/10μg
发布日期： 2024-11-30
更新日期： 2025-05-22

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产品详请

产地	中国
保存条件
品牌	EnkiLife
货号	PCH90042
用途	细胞培养用细胞因子
组织来源
细胞形态
是否是肿瘤细胞
保质期
器官来源
免疫类型
品系
生长状态
物种来源
包装规格	支
是否进口	否

产品名称	GMP Recombinant Human TGF-β3
蛋白名	TGF-β3
纯度	Greater than 95% as determined by reducing SDS-PAGE
内毒素	≤10 EU/mg
蛋白构建	Recombinant Human TGF-β3 is produced by our Mammalian cell expression system and the target gene encoding Ala 301-Ser 412 is expressed.
Accession #	P10600
蛋白标签	Tag free
表达宿主	Mammalian cell
种属	Human
预测分子量	13 kDa
蛋白形态	Lyophilized
储存缓冲液	100 mM Glycine, 150 mM NaCl, 5% mannitol and 0.01% Tween 80, pH 4.0
运输方式	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
稳定性&储存	Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 45 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
复溶	Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

分子别名

Transforming growth factor beta-3; TGFB3; TGF-beta-3; Latency-associated peptide; LAP

Bioactivity

The ED50 for this effect is ≤0.2ng/mL.

背景介绍

Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3,mammals develop a deformity known as a cleft palate.