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产品概述

产品名称（Product Name）	Lamin A/C Mouse Monoclonal Antibody
描述（Description）	Primary antibody
宿主（Host）	Mouse
应用（Application）	WB
种属反应性（Reactivity）	Human,Mouse,Rat

产品性能

偶联物（Conjugation）	Unconjugated
修饰（Modification）	Unmodified
同种型（Isotype）	IgG2a
克隆（Clonality）	Monoclonal Antibody
形式（Form）	Liquid
存放说明（Storage）	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
储存溶液（Buffer）	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
纯化方式（Purification）	Affinity Purified

免疫原

基因名（Gene Name）	LMNA
别名（Alternative Names）	LMNA; LMN1; Prelamin-A/C
基因ID（Gene ID）	4000
蛋白ID（SwissProt ID）	P02545

产品应用

稀释比（Dilution Ratio）	WB: 1/500-1/1000
蛋白分子量（Molecular Weight）	Calculated MW: 74 kDa; Observed MW: 74 kDa

研究背景

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.

研究领域

Tags & Cell Markers

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