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- 品牌：EnkiLife
- 产地：中国
- 型号：50uL
- 货号：APRab00841
- 价格： ￥1350/支
- 发布日期： 2024-12-03
- 更新日期： 2025-05-22
| 产地 | 中国 |
| 品牌 | EnkiLife |
| 保存条件 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 货号 | APRab00841 |
| 用途 | WB,IHC-P,ELISA |
| 应用范围 | |
| 抗原来源 | |
| 保质期 | |
| 抗体名 | Phospho-BRCA1 (Ser1423) Rabbit Polyclonal Antibody |
| 是否单克隆 | 否 |
| 克隆性 | |
| 靶点 | BRCA1 |
| 适应物种 | Human,Rat |
| 形态 | Liquid |
| 宿主 | Rabbit |
| 标记物 | Unconjugated |
| 包装规格 | 50uL |
| 亚型 | IgG |
| 标识物 | |
| 浓度 | % |
| 免疫原 | |
| 是否进口 | 否 |
产品概述
| 产品名称(Product Name) | Phospho-BRCA1 (Ser1423) Rabbit Polyclonal Antibody |
| 描述(Description) | Primary antibody |
| 宿主(Host) | Rabbit |
| 应用(Application) | WB,IHC-P,ELISA |
| 种属反应性(Reactivity) | Human,Rat |
产品性能
| 偶联物(Conjugation) | Unconjugated |
| 修饰(Modification) | Phosphorylated |
| 同种型(Isotype) | IgG |
| 克隆(Clonality) | Polyclonal Antibody |
| 形式(Form) | Liquid |
| 存放说明(Storage) | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 储存溶液(Buffer) | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| 纯化方式(Purification) | Affinity Chromatography |
免疫原
| 基因名(Gene Name) | BRCA1 |
| 别名(Alternative Names) | BRCA1; RNF53; Breast cancer type 1 susceptibility protein; RING finger protein 53 |
| 基因ID(Gene ID) | 672 |
| 蛋白ID(SwissProt ID) | P38398 |
产品应用
| 稀释比(Dilution Ratio) | WB: 1/500-1/1000 IHC: 1/50-1/100 ELISA: 1/10000 |
| 蛋白分子量(Molecular Weight) | Calculated MW: 208 kDa; Observed MW: 208 kDa |
研究背景
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator (PubMed:20160719).
研究领域
Epigenetics and Nuclear Signaling
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