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- 品牌：EnkiLife
- 产地：中国
- 型号：50uL
- 货号：APRab03386
- 价格： ￥1200/支
- 发布日期： 2024-12-03
- 更新日期： 2025-05-22
| 产地 | 中国 |
| 品牌 | EnkiLife |
| 保存条件 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 货号 | APRab03386 |
| 用途 | WB,IHC-P,ICC/IF,ELISA |
| 应用范围 | |
| 抗原来源 | |
| 保质期 | |
| 抗体名 | SNAI1 Rabbit Polyclonal Antibody |
| 是否单克隆 | 否 |
| 克隆性 | |
| 靶点 | SNAI1 |
| 适应物种 | Human,Mouse |
| 形态 | Liquid |
| 宿主 | Rabbit |
| 标记物 | Unconjugated |
| 包装规格 | 50uL |
| 亚型 | IgG |
| 标识物 | |
| 浓度 | % |
| 免疫原 | |
| 是否进口 | 否 |
产品概述
| 产品名称(Product Name) | SNAI1 Rabbit Polyclonal Antibody |
| 描述(Description) | Primary antibody |
| 宿主(Host) | Rabbit |
| 应用(Application) | WB,IHC-P,ICC/IF,ELISA |
| 种属反应性(Reactivity) | Human,Mouse |
产品性能
| 偶联物(Conjugation) | Unconjugated |
| 修饰(Modification) | Unmodified |
| 同种型(Isotype) | IgG |
| 克隆(Clonality) | Polyclonal Antibody |
| 形式(Form) | Liquid |
| 存放说明(Storage) | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 储存溶液(Buffer) | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| 纯化方式(Purification) | Affinity Purified |
免疫原
| 基因名(Gene Name) | SNAI1 |
| 别名(Alternative Names) | SNAH; Zinc finger protein SNAI1; Protein snail homolog 1; Protein sna |
| 基因ID(Gene ID) | 6615 |
| 蛋白ID(SwissProt ID) | O95863 |
产品应用
| 稀释比(Dilution Ratio) | WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/10000 |
| 蛋白分子量(Molecular Weight) | Calculated MW: 29 kDa; Observed MW: 29 kDa |
研究背景
Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.
研究领域
Epigenetics and Nuclear Signaling
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