Lamin A/C Rabbit Monoclonal Antibody-武汉恩玑生命科技有限公司

产品展厅

Lamin A/C Rabbit Monoclonal Antibody

品牌：EnkiLife

产地：中国

型号：50uL

货号：AMRe02200

价格： ￥1350/支
发布日期： 2024-12-03
更新日期： 2025-05-22

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产品详请

产地	中国
品牌	EnkiLife
保存条件	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
货号	AMRe02200
用途	WB,IHC-F,IHC-P,ICC/IF,IP
应用范围
抗原来源
保质期
抗体名	Lamin A/C Rabbit Monoclonal Antibody
是否单克隆	是
克隆性	Monoclonal Antibody
靶点	LMNA
适应物种	Human,Mouse,Rat
形态	Liquid
宿主	Rabbit
标记物	Unconjugated
包装规格	50uL
亚型	IgG
标识物
浓度	%
免疫原
是否进口	否

产品概述

产品名称(Product Name)	Lamin A/C Rabbit Monoclonal Antibody
描述(Description)	Recombinant Rabbit Monoclonal antibody
宿主(Host)	Rabbit
应用(Application)	WB,IHC-F,IHC-P,ICC/IF,IP
种属反应性(Reactivity)	Human,Mouse,Rat

产品性能

偶联物(Conjugation)	Unconjugated
修饰(Modification)	Unmodified
同种型(Isotype)	IgG
克隆(Clonality)	Monoclonal Antibody
形式(Form)	Liquid
存放说明(Storage)	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
储存溶液(Buffer)	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
纯化方式(Purification)	Affinity Purified

免疫原

基因名(Gene Name)	LMNA
别名(Alternative Names)	LMNA; LMN1; Prelamin-A/C
基因ID(Gene ID)	4000
蛋白ID(SwissProt ID)	P02545

产品应用

稀释比(Dilution Ratio)	WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20
蛋白分子量(Molecular Weight)	Calculated MW: 74 kDa; Observed MW: 74,63 kDa

研究背景

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.

研究领域

Tags & Cell Markers