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- 品牌：EnkiLife
- 产地：中国
- 型号：50uL
- 货号：AMRe02361
- 价格： ￥1350/支
- 发布日期： 2024-12-03
- 更新日期： 2025-05-22
| 产地 | 中国 |
| 品牌 | EnkiLife |
| 保存条件 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 货号 | AMRe02361 |
| 用途 | WB,IHC-P,IP |
| 应用范围 | |
| 抗原来源 | |
| 保质期 | |
| 抗体名 | Nucleophosmin Rabbit Monoclonal Antibody |
| 是否单克隆 | 是 |
| 克隆性 | |
| 靶点 | NPM1 |
| 适应物种 | Human |
| 形态 | Liquid |
| 宿主 | Rabbit |
| 标记物 | Unconjugated |
| 包装规格 | 50uL |
| 亚型 | IgG |
| 标识物 | |
| 浓度 | % |
| 免疫原 | |
| 是否进口 | 否 |
产品概述
| 产品名称(Product Name) | Nucleophosmin Rabbit Monoclonal Antibody |
| 描述(Description) | Recombinant Rabbit Monoclonal antibody |
| 宿主(Host) | Rabbit |
| 应用(Application) | WB,IHC-P,IP |
| 种属反应性(Reactivity) | Human |
产品性能
| 偶联物(Conjugation) | Unconjugated |
| 修饰(Modification) | Unmodified |
| 同种型(Isotype) | IgG |
| 克隆(Clonality) | Monoclonal Antibody |
| 形式(Form) | Liquid |
| 存放说明(Storage) | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 储存溶液(Buffer) | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| 纯化方式(Purification) | Affinity Purified |
免疫原
| 基因名(Gene Name) | NPM1 |
| 别名(Alternative Names) | B23; NPM |
| 基因ID(Gene ID) | 4869 |
| 蛋白ID(SwissProt ID) | P06748 |
产品应用
| 稀释比(Dilution Ratio) | WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20 |
| 蛋白分子量(Molecular Weight) | Calculated MW: 33 kDa; Observed MW: 38 kDa |
研究背景
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029).
研究领域
Epigenetics and Nuclear Signaling
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