PMS2 Rabbit Monoclonal Antibody-武汉恩玑生命科技有限公司

产品展厅

PMS2 Rabbit Monoclonal Antibody

品牌：EnkiLife

产地：中国

型号：50uL

货号：AMRe01493

价格： ￥1350/支
发布日期： 2024-12-03
更新日期： 2025-05-22

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产品详请

产地	中国
品牌	EnkiLife
保存条件	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
货号	AMRe01493
用途	WB,IP
应用范围
抗原来源
保质期
抗体名	PMS2 Rabbit Monoclonal Antibody
是否单克隆	是
克隆性	Monoclonal Antibody
靶点	PMS2
适应物种	Human
形态	Liquid
宿主	Rabbit
标记物	Unconjugated
包装规格	50uL
亚型	IgG
标识物
浓度	%
免疫原
是否进口	否

产品概述

产品名称(Product Name)	PMS2 Rabbit Monoclonal Antibody
描述(Description)	Recombinant Rabbit Monoclonal antibody
宿主(Host)	Rabbit
应用(Application)	WB,IP
种属反应性(Reactivity)	Human

产品性能

偶联物(Conjugation)	Unconjugated
修饰(Modification)	Unmodified
同种型(Isotype)	IgG
克隆(Clonality)	Monoclonal Antibody
形式(Form)	Liquid
存放说明(Storage)	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
储存溶液(Buffer)	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
纯化方式(Purification)	Affinity Purified

免疫原

基因名(Gene Name)	PMS2
别名(Alternative Names)	DNA mismatch repair gene; DNA mismatch repair protein PMS2; HNPCC4; PMS1 protein homolog 2
基因ID(Gene ID)	5395
蛋白ID(SwissProt ID)	P54278

产品应用

稀释比(Dilution Ratio)	WB: 1/500-1/1000 IP: 1/20
蛋白分子量(Molecular Weight)	Calculated MW: 96 kDa; Observed MW: 96 kDa

研究背景

Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected.

研究领域

Epigenetics and Nuclear Signaling