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- 品牌：EnkiLife
- 产地：中国
- 型号：50μg
- 货号：PEH2420
- 纯度：95
- 价格： ￥900/支
- 发布日期： 2025-06-23
- 更新日期： 2025-11-14
| 产地 | 中国 |
| 品牌 | EnkiLife |
| 货号 | PEH2420 |
| 用途 | |
| 包装规格 | 50μg |
| 纯度 | 95% |
| CAS编号 | |
| 是否进口 | 否 |
| 产品名称 | Recombinant Human Cyclophilin A (C-6His) |
| 英文名称 | Cyclophilin A/PPIA/Peptidyl-prolyl cis-trans isomerase A |
| 纯度 | Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 | <1 EU/μg as determined by LAL test. |
| 蛋白构建 | Recombinant Human Peptidyl-prolyl cis-trans isomerase A is produced by our E.coli expression system and the target gene encoding Val2-Glu165 is expressed with a 6His tag at the C-terminus. |
| Accession | P62937 |
| 表达宿主 | E.coli |
| 种属 | Human |
| 预测分子量 | 18.8 KDa |
| 制剂 | Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, 1mM DTT, pH 7.4. |
| 运输方式 | The product is shipped on dry ice/polar packs.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 | Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 | 0 |
| 分子别名 |
| Peptidyl-prolyl cis-trans isomerase A; PPIA; PPIase A; Cyclosporin A-binding protein; Rotamase A; Cyclophilin A; Cyclosporin A-binding protein; CYPA |
| 背景介绍 |
| Cyclophilin A, also known as peptidylprolyl isomerase A (PPIA), is an 18 kDa protein that catalyzes cis-trans isomerization at proline imidic peptide bonds, thereby promoting protein folding/trafficking and regulating protein activity. Cyclophilin A has multiple known functions in inflammation. Intracellularly, cyclophilin A interacts with interleukin (IL)-2 inducible T cell kinase (ITK) to tune T cell receptor signaling. Extracellularly, cyclophilin A is known to function as a leukocyte chemotactic factor. Cells secrete cyclophilin A by a vesicular secretory pathway in response to lipopolysaccharide and oxidative stress, or cyclophilin A may be released during cell death. Cyclophilin A influences inflammatory responses through its actions on immune activation and/or leukocyte trafficking. |
注意事项
本司产品仅用于科研,不用于临床诊断